![]() ![]() Grade 3 tumors have less than half of the cancer tissue forming glands.Grade 2 tumors have between 50% and 94% of the cancer tissue forming glands.Grade 1 tumors have 95% or more of the cancer tissue forming glands.In higher-grade cancers (grade 3), more of the cancer cells are disorganized and do not form glands. In lower-grade cancers (grades 1 and 2), more of the cancer cells form glands. The grade of an endometrial cancer is based on how much the cancer cells are organized into glands that look like the glands found in a normal, healthy endometrium. Adenocarcinoma, (with squamous differentiation).There are many variants (or sub-types) of endometrioid cancers including: Some of these cancers have squamous cells (squamous cells are flat, thin cells), as well as glandular cells. Endometrioid cancers start in gland cells and look a lot like the normal uterine lining (endometrium). Most endometrial cancers are adenocarcinomas, and endometrioid cancer is the most common type of adenocarcinoma, by far. They often have spread outside the uterus by the time they're diagnosed. They tend to grow and spread faster than most types of endometrial cancer. Uterine carcinosarcoma or CS (covered below in the grading section)Ĭlear-cell carcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, dedifferentiated carcinoma, and serous adenocarcinoma are less common types of endometrial adenocarcinomas.Adenocarcinoma (most endometrial cancers are a type of adenocarcinoma called endometrioid cancer - see below). ![]() (These are called histologic types.) They include: This is the most common type of cancer in the uterusĮndometrial carcinomas can be divided into different types based on how the cells look under the microscope. Types of endometrial cancerĮndometrial cancer (also called endometrial carcinoma) starts in the cells of the inner lining of the uterus (the endometrium). There is also a layer of tissue called the serosa which coats the outside of the uterus. This causes the endometrial lining to shed from the uterus and become the menstrual flow (period). If there is no pregnancy, estrogen is produced in lower amounts and more of the hormone called progesterone is made. Estrogen causes the endometrium to thicken so that it could nourish an embryo if pregnancy occurs. ![]() During a woman's menstrual cycle, hormones cause the endometrium to change. This thick layer of muscle is needed to push the baby out during birth. The body of the uterus has 2 main layers: ![]()
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